PRMT2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 25-100 Positive control: Human gastric cancer Predicted cell location: Cytoplasm
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 219-433 amino acids of human protein arginine methyltransferase 2
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	protein arginine methyltransferase 2
Database Link	NP_996845 Entrez Gene 3275 Human UniProt ID P55345
Background	Protein arginine N-methyltransferase 2?is an?enzyme?that in humans is encoded by the?PRMT2?gene. Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3; FBL; histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR; PPARG; RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation.
Synonyms	HRMT1L1
Reference Data
Protein Families	Druggable Genome

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