MAP4K3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Mouse heart tissue IHC: 25-100 Positive control: Human thyroid cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 556-867 amino acids of human mitogen-activated protein kinase kinase kinase kinase 3
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	101 kDa
Gene Name	mitogen-activated protein kinase kinase kinase kinase 3
Database Link	NP_001257354 Entrez Gene 170920 RatEntrez Gene 225028 MouseEntrez Gene 8491 Human UniProt ID Q8IVH8
Background	This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling; among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. Ubiquitously expressed in all tissues examined; with high levels in heart; brain; placenta; skeletal muscle; kidney and pancreas and lower levels in lung and liver.
Synonyms	GLK; MAPKKKK3; MEKKK 3; MEKKK3; RAB8IPL1
Reference Data
Protein Families	Druggable Genome, Protein Kinase
Protein Pathways	MAPK signaling pathway

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