MCM7 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Jurkat cells IHC: 15-50 Positive control: Human ovarian cancer Predicted cell location: Cytoplasm, Nucleus
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a C terminal 300 amino acids of human minichromosome maintenance complex component 7
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	81 kDa
Gene Name	minichromosome maintenance complex component 7
Database Link	NP_001265524 Entrez Gene 17220 MouseEntrez Gene 4176 Human UniProt ID P33993
Background	The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2; 4 and 6 proteins possesses DNA helicase activity; and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase; CDK4; is found to associate with this protein; and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Synonyms	CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146; PPP1R104
Reference Data
Protein Families	Transcription Factors
Protein Pathways	Cell cycle, DNA replication

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