LIM Kinase 1 (LIMK1) Rabbit Polyclonal Antibody
CAT#: TA325621
Rabbit Polyclonal LIMK1/2 (Thr508/505) Antibody (Phospho-specific)
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CNY 1,999.00
CNY 3,280.00
Cited in 1 publication. |
CNY 300.00
CNY 1,430.00
Specifications
Product Data | |
Applications | WB |
Recommend Dilution | WB: 1:500-1:2000; IHC: 1:50-1:200 |
Reactivity | Human, Mouse, Rat |
Modifications | Phospho-specific |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | The antiserum was produced against A synthesized peptide derived from human LIMK1/2 around the phosphorylation site of Threonine 508/505 |
Formulation | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Concentration | lot specific |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific peptide. |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | 72 kDa |
Gene Name | LIM domain kinase 1 |
Database Link | |
Background | There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is likely to be a component of an intracellular signaling pathway and may be involved in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Two splice variant have been identified. |
Synonyms | LIMK; LIMK-1 |
Reference Data | |
Protein Families | Druggable Genome, Protein Kinase |
Protein Pathways | Axon guidance, Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton |
Citations (1)
The use of this Antibodies has been cited in the following citations: |
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Transient inhibition of LIMKs significantly attenuated central sensitization and delayed the development of chronic pain
,Yang, X;He, G;Zhang, X;Chen, L;Kong, Y;Xie, W;Jia, Z;Liu, WT;Zhou, Z;,
Neuropharmacology
,PubMed ID 28669900
[LIM Kinase 1]
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