p38 (MAPK14) Mouse Monoclonal Antibody [Clone ID: 9F12]

CAT#: TA326349

Mouse monoclonal p38 alpha (MAP Kinase) Antibody



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CNY 4,550.00


货期*
4周

规格
    • 100 ug

Product images

经常一起买 (4)
Transient overexpression lysate of mitogen-activated protein kinase 14 (MAPK14), transcript variant 1
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Recombinant protein of human mitogen-activated protein kinase 14 (MAPK14), transcript variant 1, 20 µg
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Recombinant protein of human mitogen-activated protein kinase 14 (MAPK14), transcript variant 1, 100 µg
    • 100 ug

CNY 9,998.00

Specifications

Product Data
Clone Name 9F12
Applications IF, WB
Recommend Dilution WB: 1:1000
Reactivity Human, Rat
Host Mouse
Clonality Monoclonal
Immunogen Full length recombinant protein expressed in E.coli cells.
Formulation PBS, 50% glycerol
Concentration lot specific
Purification Protein G Purified
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name mitogen-activated protein kinase 14
Background The MAPK (mitogen activated protein kinase) comprises a family of ubiquitous praline-directed, proteinserine/ threonine kinases which signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms . This super family consists of stress activated protein kinases (SAPKs); extracellular signal-regulated kinases (ERKs); and p38 kinases, each of which forms a separate pathway . The kinase members that populate each pathway are sequentially activated by phosphorylation. Upon activation, p38 MAPK/SAPK2 translocates into the nucleus where it phosphorylates one or more nuclear substrates, effecting transcriptional changes and other cellular processes involved in cell growth, division, differentiation, inflammation, and death . Specifically p38 always acts as a pro-apoptotic factor with its activation leading to the release of cytochrome c from mitochondria and cleavage of caspase 3 and its downstream effector, PARP . p38 MAPK is activated by a variety of chemical stress inducers including hydrogen peroxide, heavy metals, anisomycin, sodium salicylate, LPS, and biological stress signals such as tumor necrosis factor, interleukin-1, ionizing and UV irradiation, hyperosmotic stress and chemotherapeutic drugs . As a result, p38 alpha has been widely validated as a target for inflammatory disease including rheumatoid arthritis, COPD and psoriasis and has also been implicated in cancer, CNS and diabetes .
Synonyms CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38; p38ALPHA; PRKM14; PRKM15; RK; SAPK2A
Note Detects a ~38kDa protein corresponding to the molecular mass of p38a MAPK on SDS PAGE immunoblots.
Reference Data
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Amyotrophic lateral sclerosis (ALS), Epithelial cell signaling in Helicobacter pylori infection, Fc epsilon RI signaling pathway, GnRH signaling pathway, Leukocyte transendothelial migration, MAPK signaling pathway, Neurotrophin signaling pathway, NOD-like receptor signaling pathway, Progesterone-mediated oocyte maturation, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, Toll-like receptor signaling pathway, VEGF signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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