FKBP51 (FKBP5) Mouse Monoclonal Antibody [Clone ID: Hi51B]

Specifications

Product Data
Clone Name	Hi51B
Applications	IF, WB
Recommend Dilution	WB: 1:2000
Reactivity	Canine, Human, Mouse, Rat, Rabbit, Hamster
Host	Mouse
Clonality	Monoclonal
Immunogen	Synthetic peptide corresponding to the residues of human FKBP51
Formulation	PBS, 50% glycerol
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	FK506 binding protein 5
Database Link	NP_004108 Entrez Gene 14229 MouseEntrez Gene 361810 RatEntrez Gene 2289 Human UniProt ID Q13451
Background	Hsp90 is crucial to cellular signaling by its regulation of the folding, activity, and stability of a wide range of client proteins. These client protein complexes may also contain one or more cochaperones . One class of Hsp90-binding cochaperone is composed of proteins with a characteristic tetratricopeptide repeat (TPR) domain that forms an Hsp90 binding site. Among the TPR cochaperones of Hsp90 are Hop/Sti1, protein phosphatase PP5, and members of both the FK506- and cyclosporin A-binding families of immunophilins . FK506-binding protein 51 (FKBP51) and FKBP52 are large molecular weight immunophilins that are part of the mature glucocorticoid receptor (GR) heterocomplex . The N terminal domain of each protein binds FK506 and has peptidyl-prolyl isomerase (PPIase) activity that converts prolyl peptide bonds within target proteins from cis- to trans- proline. The C-terminal domains contain the TPR repeats involved in protein-protein interactions with the Hsp90 . Although FKBP52 and FKBP51 share ~75% sequence similarity, they affect hormone binding by glucocorticoid receptor in opposing manners and have different Hsp90-binding characteristics . FK506 binding protein 51 kDa (FKBP51 or otherwise referred to as FKBP54) has been identified as a progestininducible gene. This protein is predominantly expressed in murine T cells but in humans, it is abundantly expressed in numerous tissues at levels many times higher than FKBP12. The FKBP51 gene is known to be induced by glucocorticoids .
Synonyms	AIG6; FKBP51; FKBP54; P54; PPIase; Ptg-10
Note	Detects an ~51kDa protein representing FKBP51 in cell lysate. Also detects FKBP51 in whole tissue extracts from rat kidney and rat and mouse testes.
Reference Data
Protein Families	Druggable Genome

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