Amyloid Precursor Protein (APP) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	IHC: 1:1000-1:10000, IP: 1:1000
Reactivity	Human, Mouse, Rat, Eukaryote
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic molecular mimic of soluble oligomers.
Formulation	PBS, 50% glycerol, 0.09% sodium azide
Concentration	lot specific
Purification	Protein A Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	amyloid beta precursor protein
Database Link	NP_000475 Entrez Gene 11820 MouseEntrez Gene 54226 RatEntrez Gene 351 Human UniProt ID P05067
Background	Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils.Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres . These include the amyloid- peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimers symptomology, the deposition of -synuclein in the Lewy bodies of Parkinsons disease, and accumulation of polyglutamine-containing aggregates in Huntingtons disease .
Synonyms	AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2
Note	Recognizes all types of amyloid oligomers. Appears to recognize a peptide backbone epitope that is common to amyloid oligomers, but is not found in native proteins, amyloidogenic monomer or mature amyloid fibrils.
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Alzheimer's disease

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