GRP78 (HSPA5) Mouse Monoclonal Antibody [Clone ID: 6H4.2G7]

Specifications

Product Data
Clone Name	6H4.2G7
Applications	IHC, WB
Recommend Dilution	WB: 1:2000
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	His-tagged human GRP78
Formulation	PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	heat shock protein family A (Hsp70) member 5
Database Link	NP_005338 Entrez Gene 3309 Human UniProt ID P11021
Background	GRP78 is a ubiquitously expressed, 78-kDa glucose- regulated protein, and is commonly referred to as an immunoglobin chain binding protein (BiP). The BiP proteins are categorized as stress response proteins because they play an important role in the proper folding and assembly of nascent protein and in the scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5 nontranslated region of the BiP mRNA. BiP IRES activity increases when cells are heat stressed .GRP78 is also critical for maintenance of cell homeostasis and the prevention of apoptosis . Luo et al. have provided findings that suggest GRP78 is essential for embryonic cell growth and pluripotent cell survival .In terms of diseases, GRP78 has been shown to be a reliable biomarker of hypoglycemia, to serve a neuroprotective function in neurons exposed to glutamate and oxidative stress , and its protein levels are reduced in the brains of Alzheimers patients . Also, the induction of the GRP78 protein that results in severe glucose and oxygen deprivation could possible lead to drug resistance to anti-tumor drugs .
Synonyms	BIP; GRP78; HEL-S-89n; MIF2
Note	Detects a protein with a mass of ~78kDa corresponding to GRP78
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Antigen processing and presentation, Prion diseases

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