SCN1A Mouse Monoclonal Antibody [Clone ID: S74-71]

Specifications

Product Data
Clone Name	S74-71
Applications	IHC
Recommend Dilution	WB: 1ug/ml, IHC: 0.1-1ug/ml, IF: 1-10ug/ml
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Fusion protein amino acids 1929-2009 (cytoplamsic C-terminus) of rat Nav1.1
Formulation	PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	sodium voltage-gated channel alpha subunit 1
Database Link	NP_001159435 Entrez Gene 20265 MouseEntrez Gene 81574 RatEntrez Gene 6323 Human UniProt ID P35498
Background	Voltage gated sodium channels initiate action potentials in neurons. Nav1.1 is abundant in the adult brain, and primarily localized in cell bodies. Mutations in the Nav1.1 channels cause generalized epilepsy with febrile seizures plus (GEFS+). Studies show that Nav1.1 channels also play a crucial role in the excitability of cerebellar Purkinje neurons, with major contributions to peak, persistent and resurgent forms of sodium current and to sustained action potential firing .
Synonyms	EIEE6; FEB3; FEB3A; FHM3; GEFSP2; HBSCI; NAC1; Nav1.1; SCN1; SMEI
Note	Detects ~220kDa. No cross reactivity against Nav1.2, Nav1.3 and Nav1.6
Reference Data
Protein Families	Druggable Genome, Transmembrane

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