Syt7 Mouse Monoclonal Antibody [Clone ID: S275-14]

Specifications

Product Data
Clone Name	S275-14
Applications	WB
Recommend Dilution	WB: 1:1000
Reactivity	Rat, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Fusion protein amino acids 150-239 (Cytoplasmic C2A domain) of mouse Synaptotagmin-7
Formulation	PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	synaptotagmin VII
Database Link	NP_061271 Entrez Gene 59267 RatEntrez Gene 54525 Mouse UniProt ID Q9R0N7
Background	Synaptotagmins constitute a family of memebrane-trafficking proteins that are characterized by an N-terminal transmembrane region (TMR), a variable linker, and two C-terminal C2 domains - C2A and C2B. There are 15 members in the mammalian synaptotagmin family. There are several C2-domain containing protein families that are related to synaptotagmins, including transmembrane (Ferlins, E-Syts, and MCTPs) and soluble (RIMs, Munc13s, synaptotagmin-related proteins and B/K) proteins.The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin participates in neurotransmitter release at the synapse. The first domain mediates Ca(2+)-dependent phospholipidbinding. The second C2 domain mediates interaction with Stonin 2.Synaptotagmin may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2
Synonyms	IPCA-7; MGC150517; PCANAP7; SYT-VII; SytVII
Note	Detects ~45kDa. Does not cross-react with Synaptotagmin-6 (or others). Can identify other isoforms bands at ~65kD.
Reference Data

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