Aqp2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB 1:1000-4000, IF: 1:400
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	C-terminal peptide
Formulation	PBS pH7.4, 50% glycerol and 0.09% sodium azide
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	aquaporin 2
Database Link	NP_037041 Entrez Gene 359 HumanEntrez Gene 11827 MouseEntrez Gene 25386 Rat UniProt ID P34080
Background	Aquaporins selectively conduct water molecules in and out of the cell, while preventing the passage of ions and other solutes. Known as water channels, they are integral membrane pore proteins .Aquaporin 2 is the vasopressin-regulated water channel of the apical membrane of collecting duct cells. It is located in kidney epithelial cells and usually lies dormant in intracellular vesicle membranes. When it is needed vasopressin binds to the cell surface vasopressin receptor, activating a signaling pathway that cause AQP2 containing vesicles to fuse with the plasma membrane so the AQP2 can be used by the cell . Defects in AQP2 area cause of an autosomal dominant form of nephrogenic diabetes insipidus (NDI) .
Synonyms	AQP-2; AQP-CD; aquaporin-CD; MGC34501; WCH-CD
Note	Detects ~28.8kDa. May detect larger glycosylated bands ~35-50kDa.
Reference Data

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