Dlg4 Mouse Monoclonal Antibody [Clone ID: 7E3]

Specifications

Product Data
Clone Name	7E3
Applications	IF, WB
Recommend Dilution	1ug/ml was sufficient for detection of PSD-95 on 20ug rat brain tissue extract.
Reactivity	Mouse, Rat, Bovine
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant rat PSD-95
Formulation	PBS pH7.4, 50% glycerol
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	discs large homolog 4
Database Link	NP_062567 Entrez Gene 13385 MouseEntrez Gene 29495 Rat UniProt ID P31016
Background	Postsynaptic Density protein 95 (PSD95), also known as Synapse associated protein 90kDa, is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. PSD95 is a scaffolding protein and is involved in the assembly and function of the postsynaptic density complex . These family members consist of an N-terminal variable segment followed by three amino-terminal PDZ domains, an upstream SH3 domain and an inactive carboxyl-terminal guanylate kinase (GK) domain. The first and second PDZ domain localize NMDA receptors and K+ channels to synapses, and the third binds to neuroligins which are neuronal cell adhesion molecules that interact with b-neurexins and form intercellular junctions. PSD-95 also binds to neuronal nitric oxide synthase, possibly through interactions between PDZ domains present on both proteins . Thus different PDZ domains of PSD-95 might be specialized for distinct functions .PSD95 participates in synaptic targeting of AMPA receptors through an indirect manner involving Stargazin and related transmembrane AMPA receptor regulatory proteins (TARPs) . The protein is implicated in experience dependent plasticity and plays an indispensable role in learning . Mutations in PSD95 are associated with autism .
Synonyms	FLJ97752; FLJ98574; PSD-95; PSD95; SAP-90; SAP90
Note	Detects a ~100kDa protein corresponding to the molecular mass of PSD-95 on SDS PAGE immunoblots. Additional cross-reactive bands are detected at ~80kDa and ~50kDa in rat and mouse samples.
Reference Data

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