Kcnip2 Mouse Monoclonal Antibody [Clone ID: S60-73]

Specifications

Product Data
Clone Name	S60-73
Applications	IHC, WB
Recommend Dilution	WB: 1ug/ml, IHC: 0.1-1ug/ml, IF: 1-10ug/ml
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Fusion protein amino acids 1-252 (Full length) of rat KChIP2b
Formulation	PBS pH7.4, 50% glycerol
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	Kv channel-interacting protein 2
Database Link	NP_001029133 Entrez Gene 30819 HumanEntrez Gene 80906 MouseEntrez Gene 56817 Rat UniProt ID Q9JM59
Background	There are four member of the KChiPs (Kv4 potassium channel interacting protein) family. They are all EF handcontaining proteins required for the traffic of channelforming Kv4 K+ subunits to the plasma membrane . KChiP2 expression has been found to be significantly decreased in hypertrophy and heart failure , and does so thru modulatin of intracellular concentration and calcineurin/NFAT pathways . It has also been found that KChiP2 also functionally modulates the Cav1.2 goverened Ltype calcium channel through a direct interaction between KChiP2 and the amino-terminus of Cav1.2 .
Synonyms	DKFZp566L1246; KCHIP2; MGC17241
Note	Detects ~35kDa. No cross-reactivity against rat KCHiPs 1, 3
Reference Data

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