Scnn1a Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:1000
Reactivity	Rat, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	AA46–68 of the rat sequence
Formulation	PBS, 50% glycerol and 0.09% sodium azide
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	sodium channel epithelial 1 alpha subunit
Database Link	NP_113736 Entrez Gene 20276 MouseEntrez Gene 25122 Rat UniProt ID P37089
Background	The Epithelial Sodium Channel (ENaC) is a membrane ion channel permeable to Na+ ions. It is located in the apical plasma membrane of epithelia in the kidneys, lung, colon, and other tissues where it plays a role in transepithelial Na+-ion transport . Specifically Na+ transport via ENaC occurs across many epithelial surfaces, and plays a key role in regulating salt and water absorption . ENaCs are composed of three structurally related subunits that form a tetrameric channel, , , and . The expression of its alpha and beta subunits is enhanced as keratinocytes differentiate . The beta and gamma-ENaC subunits are essential for edema fluid to exert its maximal effect on net fluid absorption by distal lung epithelia. And it has been concluded that the subunits are differentially expressed in the retina of mice with ocular hypertension, therefore the up-regulation of alpha-ENaC proteins could serve as a protection mechanism against elevated intraocular pressure .
Synonyms	Alpha-ENaC; Alpha-NaCH; BESC2; ENaCa; ENaCalpha; FLJ21883; SCNEA; SCNN1
Note	Detects ~85kDa.
Reference Data

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