Scnn1g Rabbit Polyclonal Antibody

CAT#: TA326581

Rabbit Polyclonal Anti-ENaC Gamma Antibody



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CNY 5,962.00


货期*
4周

规格
    • 100 ug

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Specifications

Product Data
Applications IF, WB
Recommend Dilution WB: 1:1000
Reactivity Rat, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen AA629–650 of the rat sequence
Formulation PBS, 50% glycerol and 0.09% sodium azide
Concentration lot specific
Purification Affinity Purified
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name sodium channel epithelial 1 gamma subunit
Background The Epithelial Sodium Channel (ENaC) is a membrane ion channel permeable to Na+ ions. It is located in the apical plasma membrane of epithelia in the kidneys, lung, colon, and other tissues where it plays a role in transepithelial Na+-ion transport . Specifically Na+ transport via ENaC occurs across many epithelial surfaces, and plays a key role in regulating salt and water absorption . ENaCs are composed of three structurally related subunits that form a tetrameric channel, , , and . The expression of its alpha and beta subunits is enhanced as keratinocytes differentiate . The beta and gamma-ENaC subunits are essential for edema fluid to exert its maximal effect on net fluid absorption by distal lung epithelia. And it has been concluded that the subunits are differentially expressed in the retina of mice with ocular hypertension, therefore the up-regulation of alpha-ENaC proteins could serve as a protection mechanism against elevated intraocular pressure .
Synonyms BESC3; ENaCg; ENaCgamma; Gamma-ENaC; Gamma-NaCH; PHA1; SCNEG
Note Detects ~83kDa.
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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