RAB21 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	RAB21 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human RAB21.
Formulation	RAB21 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	RAB21 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	RAB21, member RAS oncogene family
Database Link	NP_055814 Entrez Gene 216344 MouseEntrez Gene 299799 RatEntrez Gene 23011 Human UniProt ID Q9UL25
Background	RAB21 Antibody: RAB21 is a member of a subfamily of small GTP-binding protein genes of the Ras superfamily that plays an important role in intracellular vesicular targeting. In non-polarized Caco-2 cells, RAB21 showed a general endoplasmic reticulum (ER)-like localization, while in polarized cells, RAB21 localized to apical vesicles. RAB21 has been shown to associate with integrin subunits and to be important for receptor entry into cells via RAB5/RAB21 endosomes. The GTPase-activating protein p120RasGAP regulates cell motility by controlling the return of the endocytosed integrins to the plasma membrane by competing with RAB21 for binding to overlapping sites on the α-tail of endocytosed integrin.
Synonyms	KIAA0118
Reference Data
Protein Families	Druggable Genome

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