MMP9 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	MMP9 antibody was raised against a 16 amino acid peptide near the center of human MMP9.
Formulation	MMP9 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	MMP9 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 76 kDa; Observed: 73 kDa
Gene Name	matrix metallopeptidase 9
Database Link	NP_004985 Entrez Gene 17395 MouseEntrez Gene 81687 RatEntrez Gene 4318 Human UniProt ID P14780
Background	The matrix metalloproteinase (MMP) family are a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases (1). MMP9 degrades type IV and V collagens (2) and studies suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow (3) and plays a role in tumor-associated tissue remodeling (4).
Synonyms	CLG4B; GELB; MANDP2; MMP-9
Reference Data
Protein Families	Druggable Genome, Protease
Protein Pathways	Bladder cancer, Leukocyte transendothelial migration, Pathways in cancer

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