IL1RL2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	IL-1RL2 antibody was raised against a 16 amino acid peptide near the center of human IL-1RL2.
Formulation	IL-1RL2 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	IL-1RL2 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Predicted Protein Size	Predicted: 61 kDa; Observed: 55 kDa
Gene Name	interleukin 1 receptor like 2
Database Link	NP_003845 Entrez Gene 107527 MouseEntrez Gene 171106 RatEntrez Gene 8808 Human UniProt ID Q9HB29
Background	IL-1RL2 is a member of the interleukin 1 receptor family, but it is incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity (1). Together with IL-1RAcP, it can bind members of the IL-36 cytokine family, leading to activation of the NF-kappaB pathway (2). IL-1RL2 can also bind to IL-1F10, resulting in a decreased product of Th17 cytokines in response to immunological or LPS challenge, suggesting that one potential role of IL-1RL2 may be to modulate the immune and inflammation response (3).
Synonyms	IL-1Rrp2; IL-36R; IL1R-rp2; IL1RRP2
Reference Data
Protein Families	Druggable Genome, Transmembrane

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