EMAP II (AIMP1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 0.5 - 1 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	AIMP1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human AIMP1.
Formulation	AIMP1 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	AIMP1 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 37 kDa; Observed: 35 kDa
Gene Name	aminoacyl tRNA synthetase complex interacting multifunctional protein 1
Database Link	NP_001135888 Entrez Gene 9255 Human UniProt ID Q12904
Background	AIMP1 (Endothelial monocyte-activating polypeptide II, EMAP2) is a proinflammatory cytokine for monocytes and granulocytes (1). It is specifically induced by apoptosis and is involved in the control of angiogenesis, inflammation, and wound healing (1,2). AIMP1 was identified as one of three auxiliary factors of the mammalian aminoacyl tRNA synthetase (ARS) complex. It binds and facilitates the catalytic reaction of arginyl-tRNA synthetase (2,3). Recent studies show that CD23 plays an essential role in the AIMP1-induced immune response and might be a target in the treatment of inflammatory diseases (4).
Synonyms	EMAP2; EMAPII; HLD3; p43; SCYE1
Reference Data

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