AIMP2 Rabbit Polyclonal Antibody
CNY 5,808.00
CNY 3,080.00
CNY 300.00
CNY 1,430.00
Specifications
Product Data | |
Applications | IF, IHC, WB |
Recommend Dilution | WB: 1 - 2 ug/mL |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | AIMP2 antibody was raised against a 16 amino acid peptide near the center of human AIMP2. |
Formulation | AIMP2 antibody is supplied in PBS containing 0.02% sodium azide. |
Concentration | 1 mg/ml |
Purification | AIMP2 antibody is affinity chromatography purified via peptide column. |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | Predicted: 35 kDa; Observed: 36 kDa |
Gene Name | aminoacyl tRNA synthetase complex interacting multifunctional protein 2 |
Database Link | |
Background | AIMP2 was initially identified as a part of an aminoacyl-tRNA synthesase complex (1). It was later discovered to be a cofactor and substrate of Parkin, a Ring-type E3 ubiquitin ligase that is important for the survival of dopamine neurons in Parkinson’s disease; accumulation of AIMP2 in these cells lead to catecholaminergic cell death (2). AIMP2 can also bind to TRAF2, a key player in the TNF-alpha signaling pathway, causing the ubiquitination of TRAF2 by cIAP1, leading to TNF-alpha-dependent apoptosis (3). Finally, AIMP2 has been suggested to function as a tumor suppressor (4). |
Synonyms | JTV-1; JTV1; P38; PRO0992 |
Reference Data | |
Protein Families | Stem cell - Pluripotency |
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