UCP1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	UCP1 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human UCP1 (GenBank accession.
Formulation	UCP1 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	UCP1 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 34 kDa; Observed: 36 kDa
Gene Name	uncoupling protein 1
Database Link	NP_068605 Entrez Gene 22227 MouseEntrez Gene 24860 RatEntrez Gene 7350 Human UniProt ID P25874
Background	The mitochondrial brown fat uncoupling protein 1 (UCP1) is a member of the family of mitochondrial anion carrier proteins (MACP) (1). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells (1). UCP1 is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat (1).
Synonyms	SLC25A7; UCP
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Huntington's disease, PPAR signaling pathway

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