SUZ12 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	SUZ12 antibody was raised against a 19 amino acid peptide near the center of human SUZ12.
Formulation	SUZ12 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	SUZ12 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 81 kDa; Observed: 96 kDa
Gene Name	SUZ12 polycomb repressive complex 2 subunit
Database Link	NP_056170 Entrez Gene 23512 Human UniProt ID Q15022
Background	The Polycomb group (PcG) genes contribute to the maintenance of cell identity, cell cycle regulation and oncogenesis (1). SUZ12 (suppressor of zeste 12) is a 90 - 95 kDa member of the polycomb group of transcriptional regulators (2). It is part of a transcription repression complex termed PRC2 (Polycomb repressive complex 2) that methylates histones in the nucleus, resulting in homeotic (pattern-inducing) gene silencing. It contains one C2H2-type zinc finger region and a C-terminal VEFS-box (3,4). SUZ12 is overexpressed in breast and colon cancer. SUZ12 may be a cause of endometrial stromal tumors (5).
Synonyms	CHET9; JJAZ1
Reference Data
Protein Families	Transcription Factors

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