Prohibitin (PHB) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, IHC, WB
Recommend Dilution	WB 1:500 - 1:2000;IF 1:50 - 1:200
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human PHB
Formulation	Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	30 kDa
Gene Name	prohibitin
Database Link	NP_002625 Entrez Gene 18673 MouseEntrez Gene 25344 RatEntrez Gene 5245 Human UniProt ID P35232
Background	The prohibitins, called PHB1 and PHB2, are highly conserved proteins that are present in multiple compartments in eukaryotic cells. PHB1 is 30kDa tumor suppressor protein involved in cell cycle control. PHB1 has been found in mitochondria, the nucleus and the plasma membrane, as well as extracellularly in circulation. In mitochondria prohibitins mainly exist as membrane-bound ring complexes and function as chaperones maintaining mitochondrial protein stability during protein synthesis and transportation. In the nucleus prohibitins interact with transcription factors such as Rb and p53 to regulate target gene transcription. Extracellular prohibitin can bind and activate C3 to enhance complement activation.
Synonyms	HEL-215; HEL-S-54e; PHB1
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency, Transcription Factors

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