Grp75 (HSPA9) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, IHC, WB
Recommend Dilution	WB 1:500 - 1:2000;IF 1:50 - 1:200
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human HSPA9
Formulation	Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	74 kDa
Gene Name	heat shock protein family A (Hsp70) member 9
Database Link	NP_004125 Entrez Gene 15526 MouseEntrez Gene 291671 RatEntrez Gene 3313 Human UniProt ID P38646
Background	Grp75, also known as mortalin, is a member of Hsp70 family of chaperone proteins that is not heat-inducible. This protein is essential for transporting many mitochondrial proteins from the cytoplasm to mitochondria. Grp75 inactivates the tumor suppressor p53. Studies found that Grp75 is overexpressed in many tumor tissues and immortalized human cell lines, suggesting its role in the tumor formation. Grp75 is also implicated in cell aging, as its overexpression appears to prolong the life span of human fibroblasts.
Synonyms	CSA; GRP-75; GRP75; HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74
Reference Data
Protein Families	Stem cell - Pluripotency
Protein Pathways	RNA degradation

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