Sodium Potassium ATPase (ATP1A1) Rabbit Polyclonal Antibody
CAT#: TA326844
Rabbit polyclonal anti-ATP1A1(NaK ATPase) antibody, Loading control
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CNY 1,999.00
CNY 2,700.00
Cited in 1 publication. |
CNY 3,080.00
CNY 300.00
CNY 1,430.00
CNY 2,900.00
CNY 9,998.00
Specifications
Product Data | |
Applications | IHC, IP, WB |
Recommend Dilution | WB 1:500 - 1:1000;IP 1:20 - 1:50 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Fusion protein of human ATP1A1 |
Formulation | Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
Concentration | lot specific |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | 113 kDa |
Gene Name | ATPase Na+/K+ transporting subunit alpha 1 |
Database Link | |
Background | The Na,K-ATPase is an integral membrane heterodimer belonging to the P-type ATPase family. This ion channel uses the energy derived from ATP hydrolysis to maintain membrane potential by driving sodium export and potassium import across the plasma membrane against their electrochemical gradients. It is composed of a catalytic a subunit and a β subunit . Several phosphorylation sites have been identified for the a1 subunit. Tyr10 is phosphorylated by an as yet undetermined kinase , Ser16 and Ser23 are phosphorylated by PKC, and Ser943 is phosphorylated by PKA . All of these sites have been implicated in the regulation of enzyme activity in response to hormones and neurotransmitters, altering trafficking and kinetic properties of Na,K-ATPase. Altered phosphorylation in response to angiotensin II stimulates activity in the rat proximal tubule . Na,K-ATPase is also involved in other signal transduction pathways. Insulin regulates its localization in differentiated primary human skeletal muscle cells, and this regulation is dependent on ERK1/2 phosphorylation of the a subunit . Na,K-ATPase and Src form a signaling receptor complex that affects regulation of Src kinase activity and, subsequently, its downstream effectors. |
Synonyms | MGC3285; MGC51750 |
Reference Data | |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Cardiac muscle contraction |
Citations (1)
The use of this Antibodies has been cited in the following citations: |
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Ursolic acid ameliorates adipose tissue insulin resistance in aged rats via activating the Akt-glucose transporter 4 signaling pathway and inhibiting inflammation
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Experimental and Therapeutic Medicine
,PubMed ID 34737806
[ATP1A1]
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