NCF2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB 1:500 - 1:2000
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human NCF2
Formulation	Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	neutrophil cytosolic factor 2
Database Link	NP_000424 Entrez Gene 17970 MouseEntrez Gene 4688 Human UniProt ID P19878
Background	The phagocytic NADPH oxidase is a multiprotein enzyme that catalyzes the reduction of oxygen to superoxide in response to pathogenic invasion. The NADPH oxidase consists of 6 subunits, including the membrane-bound p91 phox and p22 phox heterodimers (also known as cytochrome b558), the cytosolic complex of p40phox, p47phox and p67phox, and the small GTPase Rac2. Activation of NADPH oxidase is initiated by cytosolic complex phosphorylation, which induces a conformational change that leads to the translocation of the cytosolic complex to the membrane and formation of an active enzyme with cytochrome b558. Defects in p47phox, often resulting from recombination between p47phox and a nearby homologous pseudogene, cause chronic granulomatous disease. Elevated oxidative stress due to increased myocardial NADPH oxidase activity may be a contributing factor in heart failure.p67phox appears to coordinate assembly of NAPDH oxidase as it associates with multiple subunits as well as the a subunit of heterotrimeric G proteins. Mutations in the corresponding p67phox gene are also associated with a form of autosomal recessive chronic granulomatous disease .
Synonyms	NCF-2; NOXA2; P67-PHOX; P67PHOX
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Leukocyte transendothelial migration

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