TDP43 (TARDBP) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IP, RIP, WB
Recommend Dilution	WB 1:500 - 1:2000;IP 1:20 - 1:50;RIP 1:20 - 1:50
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human TARDBP
Formulation	Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	43 kDa
Gene Name	TAR DNA binding protein
Database Link	NP_031401 Entrez Gene 230908 MouseEntrez Gene 23435 Human UniProt ID Q13148
Background	TDP43 (TAR DNA-binding protein 43) is involved in transcriptional regulation and exon splicing. While normal TDP43 is a nuclear protein, pathological TDP43 is a component of insoluble aggregates in patients with frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). In these disorders, TDP43 is abnormally ubiquitinated, phosphorylated and cleaved to generate carboxy-terminal fragments that are sequestered as insoluble aggregates in neuronal nuclei, perikarya, and neurites. Additionally, TDP43 inhibits the expression of the HIV-1 gene and regulates CFTR gene splicing.
Synonyms	ALS10; TDP-43
Reference Data
Protein Families	Transcription Factors

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.