PLCG 2 (PLCG2) Rabbit Polyclonal Antibody

CAT#: TA327320

PLCG2 Rabbit Polyclonal Antibody



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CNY 1,999.00

CNY 2,700.00


货期*
2周

规格
    • 100 ul

Product images

经常一起买 (4)
Transient overexpression lysate of phospholipase C, gamma 2 (phosphatidylinositol-specific) (PLCG2)
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Recombinant protein of human phospholipase C, gamma 2 (phosphatidylinositol-specific) (PLCG2), 20 µg
    • 20 ug

CNY 2,900.00
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Recombinant protein of human phospholipase C, gamma 2 (phosphatidylinositol-specific) (PLCG2), 100 µg
    • 100 ug

CNY 9,998.00

Specifications

Product Data
Applications ICC/IF, WB
Recommend Dilution WB 1:500 - 1:2000;IF 1:20- 1:100
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen Recombinant protein of human PLCG2
Formulation PBS with 0.05% proclin300,50% glycerol,pH7.3.
Concentration lot specific
Purification Affinity purification
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name phospholipase C gamma 2
Background Phosphoinositide-specific phospholipase C (PLC) plays a significant role in transmembrane signaling. In response to extracellular stimuli such as hormones, growth factors and neurotransmitters, PLC hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) to generate two secondary messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). At least four families of PLCs have been identified: PLCβ, PLC?, PLCd and PLCe. The PLCβ subfamily includes four members, PLCβ1-4. All four members of the subfamily are activated by a- or β-?-subunits of the heterotrimeric G-proteins.Phosphorylation is one of the key mechanisms that regulates the activity of PLC. Phosphorylation of Ser1105 by PKA or PKC inhibits PLCβ3 activity . Ser537 of PLCβ3 is phosphorylated by CaMKII, and this phosphorylation may contribute to the basal activity of PLCβ3. PLC? is activated by both receptor and nonreceptor tyrosine kinases .PLC? forms a complex with EGF and PDGF receptors, which leads to the phosphorylation of PLC? at Tyr771, 783 and 1245. Phosphorylation by Syk at Tyr783 activates the enzymatic activity of PLC?1. PLC?2 is engaged in antigen-dependent signaling in B cells and collagen-dependent signaling in platelets. Phosphorylation by Btk or Lck at Tyr753, 759, 1197 and 1217 is correlated with PLC?2 activity.
Synonyms APLAID; FCAS3; PLC-gamma-2; PLC-IV
Reference Data
Protein Families Druggable Genome
Protein Pathways B cell receptor signaling pathway, Calcium signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Glioma, Inositol phosphate metabolism, Leukocyte transendothelial migration, Metabolic pathways, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Non-small cell lung cancer, Pathways in cancer, Phosphatidylinositol signaling system, VEGF signaling pathway, Vibrio cholerae infection
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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