Epac1 (RAPGEF3) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 1:500 - 1:2000
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human RAPGEF3
Formulation	Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	Rap guanine nucleotide exchange factor 3
Database Link	NP_006096 Entrez Gene 223864 MouseEntrez Gene 10411 Human UniProt ID O95398
Background	EPAC1 and EPAC2 (exchange proteins activated by cyclic AMP) are guanine nucleotide exchange factors (GEFs) that catalyze the exchange of GDP for GTP, activating Rap1 and Rap2 small GTPases. Rap activation by EPAC is cAMP-dependent and mediates cAMP signaling in part through protein kinase A (PKA). EPAC signaling plays a significant role in a number of cellular processes including migration and focal adhesion formation, exocytosis, insulin signaling, axon growth and guidance and neurotransmitter release.
Synonyms	bcm910; CAMP-GEFI; EPAC; EPAC1; HSU79275
Reference Data
Protein Pathways	Leukocyte transendothelial migration, Long-term potentiation

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.