TOLLIP Rabbit Polyclonal Antibody

CAT#: TA327336

TOLLIP Rabbit Polyclonal Antibody



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热销推荐

CNY 1,999.00

CNY 2,700.00


货期*
2周

规格
    • 100 ul

Product images

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Recombinant protein of human toll interacting protein (TOLLIP), 20 µg
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Recombinant protein of human toll interacting protein (TOLLIP), 100 µg
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Specifications

Product Data
Applications ICC/IF, IHC, WB
Recommend Dilution WB 1:500 - 1:2000;IF 1:50- 1:200
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Recombinant protein of human TOLLIP
Formulation Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration lot specific
Purification Affinity purification
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name toll interacting protein
Background Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses. TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering of the TLR pathway leads to the activation of NF-?B and subsequent regulation of immune and inflammatory genes. The TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 amino acids known as the Toll/Interleukin-1 receptor (TIR) domain. Upon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains, including myeloid differentiation factor 88 (MyD88), MyD88-adaptor-like/TIR-associated protein (MAL/TIRAP), Toll-receptor-associated activator of interferon (TRIF), and Toll-receptor-associated molecule (TRAM). This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKK. Activation of IKK leads to the degradation of I?B, which normally maintains NF-?B in an inactive state by sequestering it in the cytoplasm. Tollip (Toll interacting protein) is an adaptor protein discovered to be associated with the IRAK complex and recruited to IL1-R following IL-1 stimulation. Overexpression of Tollip results in impaired NF-?B signaling. Tollip also associates directly with TLR2 and TLR4 and inhibits TLR-mediated signaling through inhibition of IRAK. Studies of Tollip deficient mice suggest that it plays a role in the regulation of inflammatory cytokines in response to IL-1 and LPS.
Synonyms IL-1RAcPIP
Reference Data
Protein Families Druggable Genome
Protein Pathways Toll-like receptor signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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