CD163 Mouse Monoclonal Antibody [Clone ID: MRQ-26]

Specifications

Product Data
Clone Name	MRQ-26
Applications	IHC
Recommend Dilution	IHC: 1:10 - 1:50
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Formulation	This antibody is supplied as cell culture supernatant diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	CD163 molecule
Database Link	NP_004235 Entrez Gene 9332 Human UniProt ID Q86VB7
Synonyms	M130; MM130; SCARI1
Note	CD163 has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression.Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in the setting of rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias by an enzyme-linked immunosorbent assay. Flow cytometry studies have confirmed that CD163 expression is limited to leukemias with monocytic differentiation. Anti-CD163 can be used to identify and enumerate myelomonocytic blasts and monocytic blasts in bone marrow biopsy for diagnosis of acute myeloid leukemia.
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transmembrane

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