Fascin (FSCN1) Mouse Monoclonal Antibody [Clone ID: 55-k2]

Specifications

Product Data
Clone Name	55-k2
Applications	IHC
Recommend Dilution	IHC: 1:100 - 1:500
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Formulation	This antibody is supplied as cell culture supernatant diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	fascin actin-bundling protein 1
Database Link	NP_003079 Entrez Gene 6624 Human UniProt ID Q16658
Synonyms	FAN1; HSN; p55; SNL
Note	Anti-fascin is a very sensitive marker for Reed-Sternberg cells and variants in nodular sclerosis, mixed cellularity, and lymphocyte depletion Hodgkin disease. It is uniformly negative in lymphoid cells, plasma cells, and myeloid cells. Anti-fascin is positive in dendritic cells. This marker may be helpful to distinguish between Hodgkin lymphoma and non-Hodgkin lymphoma in difficult cases. Also, the lack of expression of fascin in the neoplastic follicles in follicular lymphoma can be helpful in distinguishing these lymphomas from reactive follicular hyperplasia in which the number of follicular dendritic cells is normal or increased. Anti-fascin has been suggested as a prognostic marker in neuroendocrine neoplasms of the lung as well as in ovarian cancer.
Reference Data

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