SPI1 Rabbit Monoclonal Antibody [Clone ID: EPR3158Y]

Specifications

Product Data
Clone Name	EPR3158Y
Applications	IHC
Recommend Dilution	IHC: 1:50 - 1:200
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Formulation	This antibody is supplied as cell culture supernatant diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	Spi-1 proto-oncogene
Database Link	NP_001074016 Entrez Gene 6688 Human UniProt ID P17947
Synonyms	OF; PU.1; SFPI1; SPI-1; SPI-A
Note	PU.1 is a transcription factor that has been shown to be important for normal B-cell development. PU.1 belongs to the Ets family of transcription factors. It is expressed in the myeloid lineage and in immature as well as mature B-lymphocytes, with the exception of plasma cells. PU.1 is essential during early B-cell differentiation. The absence of PU.1 results in total block of B-cell development at the pre-pro stage. PU.1 is expressed in germinal center B-cells and mantle B-cells. Various lymphomas are also positive for anti-PU.1 including the following: B-chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, diffuse large cell lymphoma, diffuse large B-cell lymphoma, and nodular lymphocyte predominant Hodgkin lymphoma. Torlakovic et al. have demonstrated a quantitative positive association between a high level of expression of germinal center antigens (including PU.1) and a longer overall survival and progression-free survival in the case of follicular lymphoma.
Reference Data
Protein Families	Transcription Factors
Protein Pathways	Acute myeloid leukemia, Pathways in cancer

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