MMP1 Mouse Monoclonal Antibody [Clone ID: F15P3B6]

Specifications

Product Data
Clone Name	F15P3B6
Applications	WB
Recommend Dilution	WB, IHC
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Ovalbumin-conjugated synthetic peptide CSSFGFPRTVKH
Formulation	This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide at 0.5 mg/ml.
Concentration	lot specific
Purification	The antibody was purified by affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	54 kD
Gene Name	matrix metallopeptidase 1
Database Link	NP_002412 Entrez Gene 4312 Human UniProt ID P03956
Background	Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that degrade substances within the extracellular matrix. The MMP family includes six different groups of enzymes: collagenases, gelatinases, stromelysins, transmembrane MMPs, matrilysins and others. MMPs are secreted as proenzymes that have to be cleaved in order to be activated. Other MMPs, plasmins as well as other factors activate MMPs. MMPs are thought to play an important role in tissue remodeling associated with various physiological and pathological processes. MMP1 cleaves collagens of types I, II, III, VII and X.MMP1 is thought to play an important role in rheumatoid and osteo-arthritis pathogenesis as mediators of cartilage and bone destruction. Clone F15P3B6 has been shown to be useful for western blotting and immunohistochemistry of human MMP1.
Synonyms	CLG; CLGN
Reference Data
Protein Families	Druggable Genome, Protease, Secreted Protein
Protein Pathways	Bladder cancer, Pathways in cancer, PPAR signaling pathway

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