SYK Mouse Monoclonal Antibody [Clone ID: 4D10.2]

Specifications

Product Data
Clone Name	4D10.2
Applications	WB
Recommend Dilution	WB, IP, ICFC
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human Syk peptide aa314-339
Formulation	Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Concentration	lot specific
Purification	The antibody was purified by affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	72 kD
Gene Name	spleen tyrosine kinase
Database Link	NP_003168 Entrez Gene 6850 Human UniProt ID P43405
Background	Syk is a cytoplasmic 72 kD non-receptor tyrosine kinase that is widely expressed in hematopoietic cells. The Syk kinase associates with a number of proteins including c-Src, Lck, Lyn, Fyn, Vav1, STAT3, SHP1, Grb2, and LAT to couple immunoreceptors to downstream signaling events mediating cellular proliferation, differentiation, and phagocytosis. Syk is modified by phosphorylation on multiple tyrosine sites
Synonyms	p72-Syk
Reference Data
Protein Families	Druggable Genome, Protein Kinase
Protein Pathways	B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Natural killer cell mediated cytotoxicity

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