CTIP2 (BCL11B) Rat Monoclonal Antibody [Clone ID: 25B6]
CNY 3,531.00
CNY 4,840.00
CNY 300.00
CNY 1,430.00
Specifications
Product Data | |
Clone Name | 25B6 |
Applications | IF, WB |
Recommend Dilution | WB, IF, CHIP, IHC |
Reactivity | Human, Mouse, Zebrafish |
Host | Rat |
Clonality | Monoclonal |
Immunogen | Human Bcl11b |
Formulation | This antibody is provided in Hepes-buffered solution, pH 7.5, 0.02% NaN3. |
Purification | Protein G affinity purified. |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | 96 kD |
Gene Name | B-cell CLL/lymphoma 11B |
Database Link | |
Background | The transcription factor Bcl11b is expressed in thymus, mainly T cells. It is indispensable for T lineage development. When Bcl11b was deleted, T cells from all developmental stages acquired NK cell properties and concomitantly lost or decreased T cell-associated gene expression. These induced T-to-natural killer (ITNK) cells, which were morphologically and genetically similar to conventional NK cells, killed tumor cells in vitro, and effectively prevented tumor metastasis in vivo. Therefore, ITNKs may represent a new cell source for cell-based therapies. |
Synonyms | ATL1; ATL1-alpha; ATL1-beta; ATL1-delta; ATL1-gamma; CTIP-2; CTIP2; hRIT1-alpha; RIT1; ZNF856B |
Reference Data | |
Protein Families | Druggable Genome |
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