Prkdc Mouse Monoclonal Antibody [Clone ID: 10B1]

Specifications

Product Data
Clone Name	10B1
Applications	WB
Recommend Dilution	WB, IF
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Modified peptide
Formulation	This DNA-PKcs antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. Final antibody concentration is 0.5 mg/ml.
Concentration	lot specific
Purification	The antibody was purified by affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	470 kD
Gene Name	protein kinase, DNA activated, catalytic polypeptide
Database Link	NP_035289 Entrez Gene 5591 Human UniProt ID P97313
Background	DNA-protein kinase catalytic subunit (DNA-PKcs) also known as DNA-activated kinase is a nuclear 460-470 kD serine threonine kinase involved in double-stranded DNA break repair, VDJ recombination, and transcriptional modulation. DNA-PKcs must bind DNA ends to become active. DNA-PKcs is modified by phosphorylation and has been shown to interact with Ku70/Ku80, KIP, DNA-ligase IV, and XRCC4 proteins. Phosphorylated DNA-PKcs is upregulated after DNA damaage. The 10B1 monoclonal antibody recognizes phosphorylated human DNA-PKcs (Thr2609) and has been shown to be useful for immunofluorescence staining and Western blotting.
Synonyms	DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350; p460; XRCC7
Note	reacts with Thr2609-phosphorylated DNA-PKcs
Reference Data

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