GPR105 (P2RY14) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:200-1:2000; IHC: 1:100-1:3,000; FC: 1:50-1:600
Reactivity	Human, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide CIELKSELGRKWHKASN, corresponding to amino acid residues 172-188 of human P2Y14. 2nd extracellular loop.
Formulation	Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Reconstitution Method	Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification	Affinity purified on immobilized antigen.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	purinergic receptor P2Y14
Database Link	NP_055694 Entrez Gene 171108 RatEntrez Gene 9934 Human UniProt ID Q15391
Background	P2Y14 belongs to the P2Y receptor family that is part of the G-protein coupled receptor superfamily. To date eight functional mammalian P2Y receptors have been identified: P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13 and P2Y14. The P2Y receptor family mediates the effects of extracellular nucleotides such as ATP, ADP, UTP and in the case of P2Y14 UDP-glucose. UDP-glucose as the other nucleotides can be released to the extracellular milieu as the result of cell damage or by regulated non-lytic mechanisms. P2Y14 is expressed in several tissues including brain, lung and several cells of hematopoietic origin such as T lymphocytes and dendritic cells. The exact function of this receptor in the different tissues has not been clearly established but an involvement in chemotaxis, maturation of immature dendritic cells and neuroimmune regulation has been suggested.
Synonyms	BPR105; GPR105; P2Y14
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Neuroactive ligand-receptor interaction

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