Cacna2d2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1:200-1:2000; IHC: 1:100-1:3000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	(C)DLEAWAEKFKVLASNR, corresponding to amino acid residues 850-865 of rat Cava2d2. Extracellular, N-terminus.
Formulation	Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Reconstitution Method	Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification	Affinity purified on immobilized antigen.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	calcium voltage-gated channel auxiliary subunit alpha2delta 2
Database Link	NP_783182 Entrez Gene 9254 HumanEntrez Gene 56808 MouseEntrez Gene 300992 Rat UniProt ID Q8CFG6
Background	Voltage-gated Ca2+ channels (CaV), enable the passage of Ca2+ ions in a voltage dependent manner. These heteromeric entities are formed in part by the pore-forming a1 subunit which determines the biophysical and pharmacological properties of the channel.CaV1 and CaV2 channels are high-voltage activated (HVA) CaV channels. The a1 subunit of these channels normally interacts and associates with a2d subunit, a membrane anchored protein and CaVÃ?, a cytosolic protein.Four a2d subunits have been cloned to date: a2d1- 4. This subunit originates from a single gene. The corresponding protein is modified by post-translational cleavage yielding a a2 subunit which is disulfide bonded to the d subunit. All a2d subunits are GPI- (glycosylphosphatidylinositol) anchored proteins3. The role of this subunit is important for the membrane trafficking of the a1 subunit, and also has a role in influencing the biophysical properties of the channel.a2d can be expressed as various splice variants and expressed in a tissue specific manner. a2d2 can be detected in the brain, heart, lung, spleen and liver.Gabapentin and pregabalin are two commonly used anti-epileptic drugs. They act on CaV channels via the a2d1 and a2d2 subunits by disturbing their membrane trafficking, thereby decreasing Ca2+ currents.
Synonyms	CACNA2D; KIAA0558; LUAC11.1
Reference Data

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