Cacng4 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:200-1:2000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide (C)EKNKELRFKTKRE, corresponding to amino acid residues 208-220 of rat Cav?4. Intracellular, C-terminus.
Formulation	Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Reconstitution Method	Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification	Affinity purified on immobilized antigen.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	calcium voltage-gated channel auxiliary subunit gamma 4
Database Link	NP_542423 Entrez Gene 27092 HumanEntrez Gene 54377 MouseEntrez Gene 140725 Rat UniProt ID Q8VHW9
Background	Voltage dependent Ca2+ channels (CaV channels) are pivotal players in many physiological roles such as secretion, contraction migration and excitation.They are composed of several subunits; a1, Ã?, a2d and ?. CaV channels were originally divided into six physiological types: L, N, P, Q, R, and T type.L-type calcium channels are composed of five subunits. Cav?4, represents one of these subunits, and is one of several ? subunit proteins. It is an integral membrane protein that is thought to stabilize the Ca2+ channel in an inactive (closed) state. The encoding gene is a member of the neuronal Ca2+ channel ? subunit gene subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two similar gamma subunit-encoding genes.Cav?4, along with Cav?2, Cav?3 and Cav?8 have been associated with AMPA receptors and have been shown to modulate the trafficking of receptors to the plasma membrane as well as electrophysiological key properties.
Synonyms	MGC11138; MGC24983
Reference Data

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