Clcn5 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:200-1:2000; IHC: 1:100-1:3000
Reactivity	Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide CDYENHFNTSKGGEL, corresponding to amino acid residues 401-415 of rat CLC5. Extracellular.
Formulation	Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.025% NaN3.
Reconstitution Method	Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification	Affinity purified on immobilized antigen.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	chloride voltage-gated channel 5
Database Link	NP_058802 Entrez Gene 25749 Rat UniProt ID P51796
Background	CLC5 is a member of the voltage-dependent Cl channel family that includes nine known members. Based on sequence similarity, CLC5 is closely linked to the CLC3 and CLC4 subunits. Mutations in the CLC5 gene cause Dent's disease a X-linked renal disorder. CLC-5 is mainly found in intracellular vesicles, particularly in early endosomes vesicles, where it is believed to contribute to their acidification. The channel is mainly expressed in the kidney, although it has been found also in small intestine, brain and liver.
Synonyms	ClC-5; CLC5; CLCK2; DENTS; hCIC-K2; hClC-K2; NPHL1; NPHL2; OTTHUMP00000023279; OTTHUMP00000023281; XLRH; XRN
Reference Data

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