Nlgn1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1:200-1:2000; IHC: 1:100-1:3000
Reactivity	Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide (C)KVPSTDITLRPTRK, corresponding to amino acid residues 648-661 of rat Neuroligin 1 (). Extracellular, N-terminus.
Formulation	Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Reconstitution Method	Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification	Affinity purified on immobilized antigen.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	neuroligin 1
Database Link	NP_446320 Entrez Gene 192167 MouseEntrez Gene 116647 Rat UniProt ID Q62765
Background	The NLGN1 gene encodes a member of a family of neuronal cell surface proteins. Neuroligins act as ligands for Ã?-Neurexins, cell adhesion proteins located presynaptically. Neuroligin and Ã?-neurexin "shake hands," resulting in the connection between the two neurons and the production of a synapse. Neuroligin 1 may be involved in the formation and remodeling of central nervous system synapses.Proteins of this family may also mediate signaling by recruiting and stabilizing key synaptic components. This is done by interacting with other postsynaptic proteins to localize neurotransmitter receptors and channels in the postsynaptic density as the cell matures.Mutations in the Neuroligin genes are implicated in autism and other cognitive disorders.Neuroligins have been found to play a role in angiogenesis, specifically in human pheripheral tissues.Neuroligins bind with the help of Ca2+ to the a-neurexin LNS (laminin, neurexin and sex hormone-binding globulin-like folding units) domains and to the Ã?-neurexin LNS domain which then establishes a heterophilic trans-synaptic recognition code4. This binding results in a heterotetramer made up of a Neuroligin-1 dimer and two Neurexin-1 Ã? monomers.
Synonyms	KIAA1070; MGC45115; NL1; OTTHUMP00000211275; OTTHUMP00000211276
Reference Data

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