Kcna5 Rabbit Polyclonal Antibody

CAT#: TA328924

Rabbit polyclonal Anti-KV1.5



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CNY 11,000.00


货期*
7周

规格
    • 50 ul

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Specifications

Product Data
Applications WB
Recommend Dilution WB: 1:200-1:2000; IHC: 1:100-1:3000
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen GST fusion protein with sequence HRETDHEEQAALKEEQGIQRRESGLDTGGQRKVSCSKASFHKTGGPLEST DSIRRGSCPLEKCHLKAKSNVDLRRSLYALCLDTS RETDL, corresponding to amino acid residues 513-602 of mouse KV1.5 , (MW: 37 kDa.). Intracellular, C-terminus.
Formulation Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Reconstitution Method Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification The serum was depleted of anti-GST antibodies by affinity chromatography on immobilized GST and from antibodies cross-reactive to other Kv1 by affinity chromatography on immobilized Kv1.3-GST-fusion proteins, and then the antibody was affinity purified on
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name potassium voltage-gated channel, shaker-related subfamily, member 5
Background KV1.5 is a mammalian voltage dependent K+ channel, homologous to theDrosophila Shaker K+ channel. KV1.5 was first cloned from rat brain. EightShaker related genes exist in mammals constituting the KV1, subfamily of the large KV channel family of genes.A functional KV1 channel is either a membrane spanning homotetramer or heterotetramer, which is composed of members of the same subfamily. In addition several auxiliary subunits and intracellular proteins might interact with the channel and affect its function.The structure of KV1.5 channel is similar to all KV channels and includes six membrane spanning helixes creating a voltage sensor domain and a pore domain. The channel is expressed in cardiac and smooth muscle tissue (colon, aorta, stomach and pulmonary artery) as well as in neurons and kidney.A loss of function mutation in the gene encoding the channel was found in atrial fibrilation patients, stressing its role as a cardiac action potential regulator.The functional channel is considered transient (A-type) channel and shows prominent inactivation. Therefore, this channel activity influences the membrane potential and excitability of neurons and muscle.KV1.5 channels are sensitive to high doses of TEA (330 mM) and low doses of 4-AP (0.27 mM), the â??classicalâ? non-selective potassium channel blockers.
Synonyms ATFB7; HCK1; HK2; HPCN1; Kv1.5; MGC117058; MGC117059; PCN1
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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