Kcnip3 Rabbit Polyclonal Antibody

CAT#: TA328987

Rabbit polyclonal Anti-KChIP3



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CNY 11,000.00


货期*
7周

规格
    • 50 ul

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Specifications

Product Data
Applications WB
Recommend Dilution WB: 1:200-1:2000
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Peptide (C)SKREGIKWQRPR, corresponding to amino acid residues 18-31 of rat KChIP3 . Cytoplasmic, N-terminus.
Formulation Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Reconstitution Method Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification Affinity purified on immobilized antigen.
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name potassium voltage-gated channel interacting protein 3
Background Voltage gate K+ (KV) channels form functional entities by the assembly of four a subunits and auxiliary subunits. Various auxiliary subunits are known to interact with KV channels thereby modulating various properties such as gating, activation and inactivation of the channels as well as influence the trafficking of the channels to the cellâ??s plasma membrane. KChIPs (KV Channel Interacting Proteins) are cytoplasmic proteins which belong to the neural Ca2+ sensor (NCS) family of Ca2+ binding EF-hand proteins. To date, KChIP1-4 have been identified. All four KChIPs have a conserved C-terminal domain, which has four EF-hand-like Ca2+ binding motifs. The N-terminal region is differs among the various KChIPs and attributes different properties regarding the regulation of KV channels1. KChIPs regulate different properties of KV channels such as their cell surface expression (mediated by proper trafficking of the various subunits), channel assembly and gating. Specifically, KChIP2, 3 and 4 strongly regulate the activity of the KV4 channel family in cortical pyramidal neurons5. Furthermore, KChIP knockout mice display an increase in anxiety-like behavior compared to their wild type counterparts.KChIP1, 3, and 4 are mostly expressed in the brain while KChIP2 is expressed in the heart and in the brain.
Synonyms calsenilin; CSEN; DREAM; KCHIP3; MGC18289
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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