Scn11a Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1:200-1:2000; IHC: 1:100-1:3000
Reactivity	Human, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide CNGDLSSLDVAKVKVHND, corresponding to amino acid residues 1748-1765 of rat Nav1.9.? ? Intracellular, C-terminus.
Formulation	Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Reconstitution Method	Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification	Affinity purified on immobilized antigen.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	sodium voltage-gated channel alpha subunit 11
Database Link	NP_062138 Entrez Gene 11280 HumanEntrez Gene 29701 Rat UniProt ID O88457
Background	Voltage-gated Na+ channels (NaV) are essential for the generation of action potentials and for cell excitability. NaV channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine NaV α subunits have been cloned and named NaV1.1-1.9. Expression of the α subunit is developmentally and tissue specific. The NaV channels are classified into two groups according to their sensitivity to tetrodotoxin (TTX): TTX-sensitive and TTX-resistant channels. TTX-resistant channels have been suggested to play an important role in nociceptive transmission. Two TTX-resistant NaV channels are expressed in dorsal root ganglion (DRG) neurons, NaV1.8 and NaV1.9. The NaV1.9 channel (also called NAN or SNS2) is preferentially expressed in small-diameter DRG neurons. Recently, it was shown that BDNF activates Nav1.9 channels in the hippocampus suggesting that its expression is not restricted to DRG alone.
Synonyms	hNaN; NaN; Nav1.9; PN5; SCN12A; SNS-2; SNS2
Reference Data

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