Sstr2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:200-1:2000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide (C)ERSDSKQDKSRLNETTETQRT corresponding to residues 339-359 of rat Somatostatin Receptor Type 2? . Intracellular, C-terminus.
Formulation	Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Reconstitution Method	Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification	Affinity purified on immobilized antigen.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	somatostatin receptor 2
Database Link	NP_062221 Entrez Gene 6752 HumanEntrez Gene 20606 MouseEntrez Gene 54305 Rat UniProt ID P30680
Background	Somatostatin is a small cyclic peptide that is widely expressed throughout the central nervous system and peripheral tissues. In peripheral tissues, somatostatin exerts inhibitory effects on secretion processes, whereas in the brain, it acts as a neurotransmitter in both a stimulatory and an inhibitory manner. Somatostatin mediates its action via six high affinity G-protein-coupled receptors (SSTR1, SSTR2a, SSTR2b, SSTR3, SSTR4, and SSTR5), which are encoded by five genes. Expression of the different receptors is developmentally regulated in a time- and tissue-specific manner. Somatostatin receptors have been found on a variety of neuroendocrine tumors, such as paragangliomas, carcinoids, and breast tumors. Synthetic peptide derivatives of somatostatin have been successfully used in the treatment of neuroendocrine malignancies and in vivo imaging of tumors that are positive to somatostatin receptors. In general, SSTR2 is the most common SSTR subtype found in human tumors, followed by SSTR1, with SSTR3 and SSTR4 being less common.
Synonyms	SRIF-1; SS2R
Reference Data

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