TIAM2 Goat Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 5-10ug/ml
Reactivity	Human, Mouse, Dog
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence TLQGSKNHSNT-C, from the N Terminus of the protein sequence according to NP_036586.2
Formulation	Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
Concentration	lot specific
Purification	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	T-cell lymphoma invasion and metastasis 2
Database Link	NP_001010927 Entrez Gene 24001 MouseEntrez Gene 484045 DogEntrez Gene 26230 Human UniProt ID Q8IVF5
Background	This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Synonyms	STEF; TIAM-2
Note	IHC: In paraffin embedded Human Testis shows cytoskeletal staining in interstitial (Leydig) cells.
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Chemokine signaling pathway, Regulation of actin cytoskeleton

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