DNA Polymerase iota (POLI) Rabbit Polyclonal Antibody
CAT#: TA332469
Rabbit anti-POLI Polyclonal Antibody
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Specifications
Product Data | |
Applications | WB |
Recommend Dilution | WB 1:500 - 1:2000 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Recombinant protein of human POLI |
Formulation | Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Concentration | lot specific |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | 80 kDa |
Gene Name | polymerase (DNA) iota |
Database Link | |
Background | Mammalian Pol ι owns an unusual combination of properties: it is stimulated by Mn2+ ions, can bypass some DNA lesions and misincorporates â??Gâ? opposite template â??Tâ? more frequently than incorporates the correct â??A.â? _ It also was shown to possess dRP lyase activity. In addition, Pol ι is much more efficient in the presence of Mn2+ in comparison to Mg2+. _. It has been proposed that POLI involves in immunoglobulin somatic hypermutation (SHM), bypass of deaminated cytosines, several adducts of the purine bases. DNA strand crosslinks and is involved in DNA repair under oxidative stress. _ |
Synonyms | RAD3OB; RAD30B |
Reference Data | |
Protein Families | Druggable Genome |
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