G0 Protein alpha (GNAO1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, WB
Recommend Dilution	WB 1:500 - 1:2000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human GNAO1
Formulation	PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	354
Gene Name	G protein subunit alpha o1
Database Link	NP_066268 Entrez Gene 14681 MouseEntrez Gene 50664 RatEntrez Gene 2775 Human UniProt ID P09471
Background	Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; Galphas and Galphai bind directly to adenylyl cyclase and stimulate or inhibit its activity, leading to an increase or decrease in cAMP levels respectively.
Synonyms	EIEE17; G-ALPHA-o; GNAO; HLA-DQB1
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Long-term depression, Melanogenesis

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