BRCA1 Rabbit Polyclonal Antibody
CAT#: TA333172
Phospho-BRCA1-S988 Rabbit Polyclonal Antibody
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CNY 2,700.00
货期*
2周
规格
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Specifications
Product Data | |
Applications | IF |
Recommend Dilution | WB 1:500-1:2000, IF 1:100-1:200 |
Reactivity | Human |
Modifications | Phospho-specific |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | A phospho specific peptide corresponding to residues surrounding S988 of human BRCA1 |
Formulation | Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Concentration | lot specific |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | 1863 |
Gene Name | BRCA1, DNA repair associated |
Database Link | |
Background | This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. |
Synonyms | BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53 |
Reference Data | |
Protein Families | Druggable Genome, Transcription Factors |
Protein Pathways | Ubiquitin mediated proteolysis |
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